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Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti–IL-6) in multiple myeloma

Identifieur interne : 003640 ( Main/Exploration ); précédent : 003639; suivant : 003641

Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti–IL-6) in multiple myeloma

Auteurs : Jesús San-Miguel [Espagne] ; Joan Bladé [Espagne] ; Ofer Shpilberg [Israël] ; Sebastian Grosicki [Pologne] ; Frédéric Maloisel [France] ; Chang-Ki Min [Corée du Sud] ; Marta Polo Zarzuela [Espagne] ; Tadeusz Robak [Pologne] ; Sripada V. S. S. Prasad [Inde] ; Yeow Tee Goh [Singapour] ; Jacob Laubach [États-Unis] ; Andrew Spencer [Australie] ; María-Victoria Mateos [Espagne] ; Antonio Palumbo [Italie] ; Tom Puchalski [États-Unis] ; Manjula Reddy [États-Unis] ; Clarissa Uhlar [États-Unis] ; Xiang Qin [États-Unis] ; Helgi Van De Velde [Belgique] ; Hong Xie [États-Unis] ; Robert Z. Orlowski [États-Unis]

Source :

RBID : PMC:4123433

Descripteurs français

English descriptors

Abstract

Key Points

Adding siltuximab to VMP did not improve CR, progression-free survival, or overall survival but improved very good partial response in MM.

This suggests that the association of less than CR with long-term outcomes and the role of IL-6 in MM should be reassessed.


Url:
DOI: 10.1182/blood-2013-12-546374
PubMed: 24833354
PubMed Central: 4123433


Affiliations:

Links toward previous steps (curation, corpus...)

Le document en format XML

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<name sortKey="Puchalski, Tom" sort="Puchalski, Tom" uniqKey="Puchalski T" first="Tom" last="Puchalski">Tom Puchalski</name>
<affiliation wicri:level="2">
<nlm:aff id="aff15">Janssen Research & Development, Spring House, PA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Reddy, Manjula" sort="Reddy, Manjula" uniqKey="Reddy M" first="Manjula" last="Reddy">Manjula Reddy</name>
<affiliation wicri:level="2">
<nlm:aff id="aff15">Janssen Research & Development, Spring House, PA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Uhlar, Clarissa" sort="Uhlar, Clarissa" uniqKey="Uhlar C" first="Clarissa" last="Uhlar">Clarissa Uhlar</name>
<affiliation wicri:level="2">
<nlm:aff id="aff15">Janssen Research & Development, Spring House, PA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Qin, Xiang" sort="Qin, Xiang" uniqKey="Qin X" first="Xiang" last="Qin">Xiang Qin</name>
<affiliation wicri:level="2">
<nlm:aff id="aff15">Janssen Research & Development, Spring House, PA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Van De Velde, Helgi" sort="Van De Velde, Helgi" uniqKey="Van De Velde H" first="Helgi" last="Van De Velde">Helgi Van De Velde</name>
<affiliation wicri:level="1">
<nlm:aff wicri:cut="; and" id="aff16">Janssen Research & Development, Beerse, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Janssen Research & Development, Beerse</wicri:regionArea>
<wicri:noRegion>Beerse</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Xie, Hong" sort="Xie, Hong" uniqKey="Xie H" first="Hong" last="Xie">Hong Xie</name>
<affiliation wicri:level="2">
<nlm:aff id="aff15">Janssen Research & Development, Spring House, PA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Janssen Research & Development, Spring House</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Orlowski, Robert Z" sort="Orlowski, Robert Z" uniqKey="Orlowski R" first="Robert Z." last="Orlowski">Robert Z. Orlowski</name>
<affiliation wicri:level="2">
<nlm:aff id="aff17">The University of Texas MD Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Texas</region>
</placeName>
<wicri:cityArea>The University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antibodies, Monoclonal (administration & dosage)</term>
<term>Antineoplastic Combined Chemotherapy Protocols (administration & dosage)</term>
<term>Boronic Acids (administration & dosage)</term>
<term>Bortezomib</term>
<term>Chromosome Deletion</term>
<term>Chromosomes, Human, Pair 17</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Immunoglobulin A (blood)</term>
<term>Interleukin-6 (antagonists & inhibitors)</term>
<term>Male</term>
<term>Melphalan (administration & dosage)</term>
<term>Middle Aged</term>
<term>Multiple Myeloma (blood)</term>
<term>Multiple Myeloma (drug therapy)</term>
<term>Multiple Myeloma (genetics)</term>
<term>Multiple Myeloma (mortality)</term>
<term>Prednisone (administration & dosage)</term>
<term>Pyrazines (administration & dosage)</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Acides boroniques (administration et posologie)</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps monoclonaux (administration et posologie)</term>
<term>Bortézomib</term>
<term>Chromosomes humains de la paire 17</term>
<term>Délétion de segment de chromosome</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunoglobuline A (sang)</term>
<term>Interleukine-6 (antagonistes et inhibiteurs)</term>
<term>Melphalan (administration et posologie)</term>
<term>Myélome multiple (génétique)</term>
<term>Myélome multiple (mortalité)</term>
<term>Myélome multiple (sang)</term>
<term>Myélome multiple (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Prednisone (administration et posologie)</term>
<term>Protocoles de polychimiothérapie antinéoplasique (administration et posologie)</term>
<term>Pyrazines (administration et posologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Survie sans rechute</term>
<term>Taux de survie</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en">
<term>Antibodies, Monoclonal</term>
<term>Boronic Acids</term>
<term>Melphalan</term>
<term>Prednisone</term>
<term>Pyrazines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en">
<term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr">
<term>Acides boroniques</term>
<term>Anticorps monoclonaux</term>
<term>Melphalan</term>
<term>Prednisone</term>
<term>Protocoles de polychimiothérapie antinéoplasique</term>
<term>Pyrazines</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr">
<term>Interleukine-6</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en">
<term>Interleukin-6</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>Immunoglobulin A</term>
<term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Multiple Myeloma</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr">
<term>Immunoglobuline A</term>
<term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr">
<term>Myélome multiple</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Bortezomib</term>
<term>Chromosome Deletion</term>
<term>Chromosomes, Human, Pair 17</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte d'âge moyen</term>
<term>Bortézomib</term>
<term>Chromosomes humains de la paire 17</term>
<term>Délétion de segment de chromosome</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Survie sans rechute</term>
<term>Taux de survie</term>
<term>Études de suivi</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<title>Key Points</title>
<p>
<list list-type="bullet">
<list-item>
<p>Adding siltuximab to VMP did not improve CR, progression-free survival, or overall survival but improved very good partial response in MM.</p>
</list-item>
<list-item>
<p>This suggests that the association of less than CR with long-term outcomes and the role of IL-6 in MM should be reassessed.</p>
</list-item>
</list>
</p>
</div>
</front>
</TEI>
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<list>
<country>
<li>Australie</li>
<li>Belgique</li>
<li>Corée du Sud</li>
<li>Espagne</li>
<li>France</li>
<li>Inde</li>
<li>Israël</li>
<li>Italie</li>
<li>Pologne</li>
<li>Singapour</li>
<li>États-Unis</li>
</country>
<region>
<li>Alsace (région administrative)</li>
<li>Catalogne</li>
<li>Communauté de Madrid</li>
<li>Grand Est</li>
<li>Massachusetts</li>
<li>Pennsylvanie</li>
<li>Piémont</li>
<li>Région capitale de Séoul</li>
<li>Texas</li>
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<li>Turin</li>
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</list>
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<name sortKey="Polo Zarzuela, Marta" sort="Polo Zarzuela, Marta" uniqKey="Polo Zarzuela M" first="Marta" last="Polo Zarzuela">Marta Polo Zarzuela</name>
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<noRegion>
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<country name="France">
<region name="Grand Est">
<name sortKey="Maloisel, Frederic" sort="Maloisel, Frederic" uniqKey="Maloisel F" first="Frédéric" last="Maloisel">Frédéric Maloisel</name>
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<country name="Corée du Sud">
<region name="Région capitale de Séoul">
<name sortKey="Min, Chang Ki" sort="Min, Chang Ki" uniqKey="Min C" first="Chang-Ki" last="Min">Chang-Ki Min</name>
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<country name="Singapour">
<noRegion>
<name sortKey="Tee Goh, Yeow" sort="Tee Goh, Yeow" uniqKey="Tee Goh Y" first="Yeow" last="Tee Goh">Yeow Tee Goh</name>
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<country name="États-Unis">
<region name="Massachusetts">
<name sortKey="Laubach, Jacob" sort="Laubach, Jacob" uniqKey="Laubach J" first="Jacob" last="Laubach">Jacob Laubach</name>
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<name sortKey="Orlowski, Robert Z" sort="Orlowski, Robert Z" uniqKey="Orlowski R" first="Robert Z." last="Orlowski">Robert Z. Orlowski</name>
<name sortKey="Puchalski, Tom" sort="Puchalski, Tom" uniqKey="Puchalski T" first="Tom" last="Puchalski">Tom Puchalski</name>
<name sortKey="Qin, Xiang" sort="Qin, Xiang" uniqKey="Qin X" first="Xiang" last="Qin">Xiang Qin</name>
<name sortKey="Reddy, Manjula" sort="Reddy, Manjula" uniqKey="Reddy M" first="Manjula" last="Reddy">Manjula Reddy</name>
<name sortKey="Uhlar, Clarissa" sort="Uhlar, Clarissa" uniqKey="Uhlar C" first="Clarissa" last="Uhlar">Clarissa Uhlar</name>
<name sortKey="Xie, Hong" sort="Xie, Hong" uniqKey="Xie H" first="Hong" last="Xie">Hong Xie</name>
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